There are debuts for American signings Katana Howard and Nick James at fly-half and prop, while fellow countrywoman Catie Benson is given her first start for the Sharks.
Jess Kavanagh re-enters the side having been off following a concusion. Laura Perrin replaces Alicia Calton in the centre.
Lauren Delany, fresh back from international duty for Ireland, starts on the right wing.
Mhairi Grieve retains the captaincy as Beth Stafford starts on the bench, having also been absent after an HIA.
See the full squad below.
